The extent of osteolysis in patients who underwent total hip arthroplasty depended on polyethylene wear rate, and extent and wear rate correlated with age, physical activity, patient walking capacity and the abduction of the acetabular component, according to study results.
Researchers analyzed 75 total hip arthroplasties (THAs) that included a titanium alloy, non-cemented, multiple-hole model implant with hydroxyapatite coating. Average evolution time was 13.67 years.
The researchers observed osteolytic lesions in 56 cases, with 17 lesions classified as advanced disease. Nineteen cases had no osteolytic lesions detected through MRI, with 13 of the 19 cases showing no sign of disease and six displaying granulomatous lesions without osteolysis.
Most of the cases had a totally or predominantly peripheral pattern, or totally or predominantly continuous lesions; however, very few cases exhibited totally or predominantly central lesions, according to the researchers.
The researchers found osteolysis in 20 of 118 screws. Polyethylene (PE) wear, strolling, the patient’s degree of activity and acetabular abduction were found to have a direct, statistically significant relationship.
An association was also noted between PE wear rate and the magnitude of osteolysis, and a statistically significant relationship was seen between the magnitude of osteolysis and years of evolution, strolling, physical activity and acetabular abduction, according to the researchers. However, there was an inverse relation with age at the time of initial surgery.
Disclosure: This study received financial or material support from Johnson & Johnson Medical Iberia.